CS/B.Sc.(H)/(Genetics/Mol-Bio.)/SEM-6/MLG-603/2013
2013
MOLECULAR HUMAN GENETICS
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
10x1 = 10
i) Which chromosome possesses lowest number/density
of genes ?
a) 13
b) Y
c) 1
d) 22.
ii) Locus heterogeneity means
a) same disease by mutations at different loci
b) existence of many different disease-causing alleles
at same locus
c) complex patterns of inheritance occurs from the
same locus
d) variable expression of a gene in the same locus.
iii) Which year map based Cystic Fibrosis Gene was
discovered on chromosome 7q ?
a) 1987
b) 1989
c) 1992
d) 1998.
iv) Which type of vectors are mostly used in gene therapy
clinical trials ?
a) Retrovirus
b) Pox virus
c) Vaccinia virus
d) Adeno-associated virus.
v) First human gene therapy trial was done using
a) MoMLV-based delivery vector
b) Liposome-based delivery
c) Human Artificial chromosome based delivery
d) Non-viral based delivery.